Led by Dr Simon Johnson at Northumbria University, this cutting-edge study will investigate three innovative strategies that have shown promise in pre-clinical models. The aim is to better understand how these approaches work and determine whether combining them could lead to more effective treatments for mitochondrial disease.
Three promising strategies
The project will focus on:
- Targeting the immune system: Looking into how tweaking immune system activity could help improve the health of mitochondria.
- Protein production pathways: Studying how changes in how proteins are made might help solve problems with mitochondrial dysfunction.
- Lowering oxygen levels: Investigating whether reducing oxygen levels can help mitochondria to work better.
By studying these mechanisms in human patient cells, the research seeks to uncover insights that could streamline clinical trials and pave the way for transformative therapies.
Why the immune system?
Studying the immune system is important for understanding mitochondrial diseases because the immune system helps the body deal with stress and damage. In mitochondrial diseases, where the mitochondria struggle to make enough energy, the immune system can sometimes overreact, causing more harm through inflammation. By learning how the immune system and mitochondria affect each other, scientists can find new ways to reduce this damage and improve cell health. This could lead to treatments that address the problem at its source instead of just managing the symptoms, improving the quality of life of patients.
Made possible by you
This ground-breaking research is only possible thanks to the incredible generosity of our supporters. Every donation and fundraising effort contributes to advancing studies like this one, bringing hope to families affected by mitochondrial disease.
What’s next?
This is just one of several exciting research projects we’re proud to support. Keep an eye on our website and follow us on social media to stay updated on the latest developments in mitochondrial research.
A shared vision
Funding innovative medical research is central to our mission – not only for the potential breakthroughs it promises but also for the immediate impact it has on improving patient care. Together, we’re shaping a future where mitochondrial diseases can be better understood, treated and – one day – cured.